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Nonetheless, in a small crossover study of 26 human diabetic patients, 4 weeks of ebselen treatment did not alter plasma levels of oxidative stress markers, such as GSH/GSSG, isoprostanes, and nitrotyrosine, compared to placebo treatment [82]

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Furthermore, it has been observed that increased expression of the Klotho gene correlates with a decrease in apoptotic cell count following oxidative stress-induced injury (Mitobe et al., 2005)

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